PLOD1 and obesity due to melanocortin 4 receptor deficiency: [2] Conversely, CC can enhance FSH and LH levels by inhibiting estrogen’s negative feedback and improving pituitary sensitivity (27, 39), which proves advantageous for treating patients with obesity [3]; The improvement of pituitary sensitivity induced by CC can compensate for the reduced hypothalamic-pituitary function and LH levels observed in women with obesity.