Mechanistically, ESSENCE increases carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) stability via preventing E3 ligase KEAP1 (Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1)-mediated CAD ubiquitination and proteasome degradation, thereby promoting CAD-regulated ferroptosis defense and subsequent tumor progression. The gene discussed is CAD; the disease is neoplasm.