MYCN and neuroblastoma: MYCN encodes a core transcription factor essential for embryonic development and the normal physiological processes of the nervous system, playing a critical role in regulating the proliferation and differentiation of neuroblasts.[47] In neuroblastoma (NB) patients, MYCN amplification is typically associated with increased tumor aggressiveness and malignancy.[48] A comprehensive analysis of medullary cells identified a population of PCC cells with elevated MYCN (N‐Myc) expression (Figure 5).