This analysis was informed by established markers for the three cortical layers described in the literature (zG, zona glomerulosa: DACH1, VSNL1; zF, zona fasciculata: CCN3, NCAM1; zR, zona reticularis: CYB5A, SULT2A1).[16] InferCNV in Figure S3 (Supporting Information) revealed a significant clustering of tumor cells within the three pathological adrenal cortical subtypes: zG/zF‐ACA‐No, zG/zF‐ACA‐Conn, and zR‐ACA‐Conn. This evidence concerns the gene CCN3 and neoplasm.