MC2R and adrenal cortex carcinoma: SF1 regulates steroidogenic enzymes, including STAR, CYP11A1, and MC2R, and is associated with adrenal cortical tumors.[28, 29, 30] To build on these findings, the expression profiles of 125 downregulated genes and 83 upregulated genes following the knockdown of SF‐1 from public data were analyzed (GSE43035) (Figure S6A,B, Supporting Information).