Polyphenols, particularly curcumin, resveratrol, and polydatin, have demonstrated multitarget ‘pleiotropic’ effects that may disrupt these oncogenic signaling pathways, which regulate different stages of the development of BC, including the NF‐κB, PI3K/Akt/mTOR, JNK, JAK/STAT, MAPK, and ERK1/2 pathways; EMT and MMP‐2 and MMP‐9; p53 and microtubule‐associated protein light chain 3 (LC3); and cell cycle arrest, oxidation state, and angiogenesis. The gene discussed is MAPK8; the disease is breast cancer.