Fibrosis is the primary cause of adenomyosis development and accounts for the ineffective treatment in clinical practices.[26] To investigate the regulatory mechanism of CNN1+ stromal fibroblasts in fibrosis, we analyzed cell–cell interaction in the lesion microenvironment (lesion‐env, as shown in Figures7A and S9C, Supporting Information) by NicheNet.[37] We found some prioritized ligands that explained the upregulation of fibrosis‐related target genes in CNN1+ stromal ecotypes (Figure 7B). Here, CNN1 is linked to adenomyosis.