GATA6 and adenomyosis: Consistent with our result, GATA6 was reported to show higher expression levels in stromal fibroblasts of adenomyosis.[93] Additionally, high GATA6 expression might cause tracheal fibrosis by triggering fibroblast activation.[94] In the lesion microenvironment, the mediators produced by epithelial ecotypes, stromal ecotypes, endothelial ecotypes, immune ecotypes, SMC ecotypes, and PV ecotypes worked together to form a profibrotic environment.