Knockdown of SNAI1 mitigated ACBD3 deficiency-induced cell migration and invasion and anoikis resistance in epithelial H441 cells (Fig. 7K–M and Fig. S7B), suggesting that ACBD3 suppresses lung cancer cell dissemination through inhibiting the NOTCH-SNAI1 axis (Fig. 7N). The gene discussed is ACBD3; the disease is lung cancer.