Conversely, ectopic expression of ACBD3 in mesenchymal NSCLC H1299 and CALU1 cells suppressed cell migration and invasion and enhanced anoikis without affecting cell proliferation on monolayer (Fig.6H–K; Fig. S6C and D), suggesting that ACBD3 acts as a suppressor of NSCLC metastasis. Here, ACBD3 is linked to non-small cell lung carcinoma.