SOX9 and Hepatic fibrosis: In addition, deletion of TFE3 in F3KO led to a reduction in liver fibrosis, a decrease in SOX9 expression in hepatocytes, and normalization of mTORC1 activity, as demonstrated by P-S6 immunostaining and immunoblot for P-4EBP1 (Figs. 6E and S8B).