IDH1 and neoplasm: Lipid catabolism and lipid oxidation pathways were also downregulated upon expression of IDH1 R132Q versus R132H (Fig. 3), suggesting that the use of lipids as a fuel source is more critical in R132H-expressing xenografts than R132Q; indeed, β-oxidation has been shown to be an important adaptive mechanism in R132H tumor models (43).