Overall, compared to IDH1 R132H, R132Q-expressing chondrosarcoma tumor models experienced significant changes in pathways including DNA damage, Wnt and EGFR signaling, lipid metabolism, carboxylic acid catabolism, and collagen/ECM remodeling likely facilitated by altered CpG methylation and as well as by non-CpG-methylation mechanisms. The gene discussed is EGFR; the disease is chondrosarcoma.