IDH1 and cancer: Pathways predicted to be hypomethylated in IDH1 R132Q versus R132H chondrosarcoma models involved p38 MAPK, which helps regulate cell differentiation, growth, and death (47), RNA pol II transcription cofactor binding, vesicle trafficking, fatty acid and organelle transport pathways, and non-canonical Wnt signaling that can drive proliferation and migration in cancer (48) (Fig. 2J).