IDH1 and neoplasm: RRBS analysis highlighted that regions associated with nucleic acid phosphodiester bond hydrolysis and DNA replication and repair were hypermethylated in IDH1 R132Q-expressing U87MG tumor xenografts versus R132H (Fig. 4I), reminiscent of DNA damage pathways hypermethylated in R132Q HT1080∗ tumors (Fig. 2J).