IDH1 and central nervous system cancer: We selected well-characterized cancer-derived and non-cancer-derived cell lines commonly used to model IDH1 mutations in gliomas and chondrosarcomas: normal human astrocytes (NHA), U87MG glioma cells, C28 chondrocytes, and a modified HT1080 sarcoma line with the endogenous IDH1 R132C mutation removed to generate IDH1−/+, designated here as HT1080∗.