RNAseq analysis again showed many cancer pathways upregulated in IDH1 R132Q-expressing HT1080∗ xenografts versus R132H outside of genes identified in RRBS analysis, including proto-oncogenes c-myc (MYC), EGFR, vascular endothelial growth factor c (VEGFC), Ras-like proto-oncogene A (RALA), casitas B-lineage lymphoma E3 ubiquitin ligase (CBL), and ETS proto-oncogene 1 (ETS1) (Figs. 3, S9, and S11). This evidence concerns the gene CBL and cancer.