We found that tumors expressing IDH1 R132Q had increased D2HG levels and larger tumors compared to WT and R132H, but the glioma and chondrosarcoma xenograft tumor models had highly variable consequences on genome methylation and gene expression, with increased pro-tumorigenic pathways upregulated in xenograft tumors upon expression of IDH1 R132Q. Here, IDH1 is linked to glioma.