Increased hypermethylation and hypomethylation are well-documented in R132H IDH1-mutated tumor models and tumor tissue (3, 9, 28, 62, 63, 64, 65, 66, 67, 68), though the mechanisms and consequences of hypomethylation are not understood (62, 63, 64, 65). The gene discussed is IDH1; the disease is neoplasm.