F2 and coronary artery disorder: Genetically proxied prothrombin levels were further associated with increased risk of CAD (OR, 1.17 [95% CI, 1.06–1.29]; P=2.38×10−3) and with protection from menorrhagia (OR, 0.62 [95% CI, 0.51–0.76]; P=3.5×10−6).