TFPI and ischemic stroke: Additional experimental work is also needed to determine the mechanisms underlying the opposing associations of genetically proxied soluble PROCR levels with VTE and arterial thrombosis and the protective association of genetically proxied γ′ fibrinogen with ischemic stroke and VTE.47 While there was evidence for protective associations between circulating tissue factor pathway inhibitor and urokinase levels and ischemic stroke, evidence for colocalization was weak, and this finding requires further investigation in larger data sets.