BCHE and Anxiety: Furthermore, transgenic excess of the AChE-targeting CholinomiR miR-132 was incompatible with fetal survival in mice [93]; also, cholinesterase enzymes in male mice were directly influenced by prenatal physical and psychological stress, and hyperexcitability of the cholinergic neurons in the latero-dorsal tegmentum may cause anxiety-like behaviors and memory impairment [94].