Adjusted HRs (95% CIs) for the highest versus lowest YKL-40 category were 2.4 (1.6–3.7) for obesity-related, 2.6 (1.7–4.1) for gastrointestinal, 44.2 (12.8–153.4) for liver, and 4.2 (1.3–14.1) for bladder cancers. Here, CHI3L1 is linked to urinary bladder cancer.