PDCD1 and non-small cell lung carcinoma: In this study, we demonstrated that non-invasive quantification of PD-L1 with [99mTc]NM-01 SPECT/CT may determine spatial and temporal heterogeneity of PD-L1 expression and potentially may predict early metabolic response to treatment with anti-PD-1 therapy with/without chemotherapy in advanced NSCLC.