VEGFA and hemangioma: Its potential mechanisms include vasoconstriction, inhibition of angiogenesis through suppression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and induction of apoptosis of endothelial cells and hemangioma-derived stem cells.9 Despite its widespread use, propranolol is still not suitable for all IH patients.10 Vincristine and interferon, though effective, are typically reserved for severe cases due to their associated toxicity and side effects.7,11