It also suggests that ATR inhibitors, VEGF inhibitors, and mTOR inhibitors, all of which have low IC50 values, suggest that ATR-Mediated DNA Damage Response, HIF signaling pathway, the VEGF signaling pathway, and the PI3K/AKT/mTOR signaling pathway, might be the key pathways to treat IH. Here, AKT1 is linked to isolated hemihyperplasia.