We first examined the SIRT2 expression and GSH levels in a list of human RCC cell lines, and observed a well-correlated expression pattern (Fig. 4A), with high GSH level corresponding to higher SIRT2 expression (CAKI-1, A498) versus low GSH with lower SIRT2 expression (769-P, 786-O, ACHN, G401). This evidence concerns the gene SIRT2 and renal cell carcinoma.