Our findings that ferroptosis inhibitor Fer-1, instead of other cell death inhibitors (apoptosis, necroptosis), could efficiently protect cells from TBH-induced cell death in SIRT2-knocked down CAKI-1 cells (Fig. S7A), suggest that SIRT2-GCLC-GSH axis may play pivotal roles in regulating sensitivity to ferroptosis in cancer cells suffering from oxidative stress. The gene discussed is GCLC; the disease is cancer.