Human renal cell carcinoma (RCC) cells ACHN were treated with 700 μM TBH, and the results showed that cellular GSH level was decreased at 3 h post treatment, but rapidly increased thereafter (Fig. 2A), suggesting that oxidative stress leads to exhaustion of cellular GSH at earlier treatment which could be rapidly compensated through activated GCLC activity. The gene discussed is GCLC; the disease is hereditary clear cell renal cell carcinoma.