LEF1 and neoplasm: Non-expanded T cells showed increased expression of naive-memory markers (TCF7, IL7R, CCR7, SELL, and LEF1) as well as immune-regulatory markers such as FOXP3. Unlike blood samples, expanded T cells in tumor samples showed increased expression of genes such as CXCL13 compared to non-expanded T cells (Figures 1D and 1F; Table S2).