For non-responders, the obtained markers include FOS, ZNF683, CTSC, GZMH, ANXA1, and XCL2. The upregulation of FOS expression in tumor-infiltrating T cells was previously shown to promote tumor growth,39 and XCL2 was shown to be expressed in tumor-associated CD8+ T cells expressing exhaustion markers across four tumor types.40 Here, CTSC is linked to neoplasm.