Data-driven machine learning performed on commonly available variables (age at diagnosis, sex, BMI, HbA1c) and HOMA2-B and HOMA2-IR in newly diagnosed individuals with diabetes from southern Sweden identified five reproducible clusters: severe autoimmune (SAID), insulin-deficient (SIDD) and insulin-resistant (SIRD) diabetes and mild obesity-related (MOD) and age-related (MARD) diabetes (Fig. 2) [92]. This evidence concerns the gene INS and diabetes mellitus.