In previously insulin-naive participants, 10.3–13.6% of hypoglycaemia alert values and 9.6–18.9% of clinically significant or severe hypoglycaemic episodes were attributed to physical activity in the icodec arms across ONWARDS 1, 3 and 5, while 10.8–16.3% and 6.6–8.6%, respectively, were attributed to physical activity in the once-daily insulin comparator arms of these trials (Fig. 1). The gene discussed is INS; the disease is Hypoglycemia.