INS and Hypoglycemia: In insulin-experienced participants, 13.1–22.6% of hypoglycaemia alert values and 9.7–19.1% of clinically significant or severe hypoglycaemic episodes across ONWARDS 2 and 4 were attributed to physical activity in the icodec arms, while 19.0–20.6% and 19.8–31.0%, respectively, were attributed to physical activity in the once-daily insulin comparator arms (Fig. 1).