Next, five LMRGs with significant prognosis values were screened in the DLBCL cohort via COX regression and LASSO estimation, including HIF-1 A, MYC, SDHA, NDUFB11, and PITRM1. Among these key genes, MYC and SDHA acted as risk factors, i.e., increased expressions of MYC and SDHA in DLBCL patients had poor outcomes, while other key genes were protective factors in DLBCL patients. The gene discussed is NDUFB11; the disease is diffuse large B-cell lymphoma.