Our research has demonstrated that the inhibition of MLL1 and WDR5—via MM-102 and OICR-9429, respectively—as well as siRNA targeting MLL1/WDR5 complex, reduces p16INK4a expression and H3K4 tri-methylation in a mouse model of IRI-induced renal fibrosis. This evidence concerns the gene KMT2A and renal fibrosis.