To further investigate the impact of IFI30 on senescent cells and the cellular microenvironment, we assessed the effect of IFI30 knockdown on the expression of senescence‐associated secretory phenotype (SASP)‐related cytokines and growth factors associated with ESCC progression in KYSE150 and KYSE450 cells using qPCR. This evidence concerns the gene IFI30 and esophageal squamous cell carcinoma.