The results revealed that IFI30 knockdown in KYSE150 and KYSE450 cells increased levels of Bax, Cytc, caspase‐7, cleaved caspase‐7, and cleaved caspase‐3, while decreasing Bcl‐2 levels (Figure 5c), indicating that IFI30 knockdown promotes apoptosis in ESCC cells. This evidence concerns the gene BCL2 and esophageal squamous cell carcinoma.