MC4R and Obesity: In patients with BBS, dysfunction of the immotile primary cilia in the hypothalamic melanocortin‐4 receptor (MC4R) pathway responsible for controlling energy balance, hunger, and satiety appears to be a major contributor to severe pathological hunger, known as hyperphagia, accompanied by food‐seeking behaviors that drive the development of early‐onset severe obesity.2, 5, 22, 23, 24, 25, 26, 27