In patients with BBS, dysfunction of the immotile primary cilia in the hypothalamic melanocortin‐4 receptor (MC4R) pathway responsible for controlling energy balance, hunger, and satiety appears to be a major contributor to severe pathological hunger, known as hyperphagia, accompanied by food‐seeking behaviors that drive the development of early‐onset severe obesity.2, 5, 22, 23, 24, 25, 26, 27. The gene discussed is MC4R; the disease is Bardet-Biedl syndrome.