Once‐weekly insulin was associated with a statistically significant increase in the incidence of level 1 nocturnal hypoglycemia (RR: 1.09 with 95% CI [1.04, 1.15], p = 0.0009) and level 2 nocturnal hypoglycemia (RR: 1.24 with 95% CI [1.10, 1.40], p = 0.0004). The gene discussed is INS; the disease is Hypoglycemia.