the pooled studies were homogeneous (p = 0.66, I2 = 0%), and once‐weekly insulin was associated with a statistically significant increase in the rates of level 2 hypoglycemia (RR: 1.06 with 95% CI [1.01, 1.12], p = 0.01) (Table S2). The gene discussed is INS; the disease is Hypoglycemia.