BIN1 and early-onset autosomal dominant Alzheimer disease: However, after adjusting for false discovery rate (FDR), only 8 proteins showed a statistically significant correlation with Alzheimer's disease (FDR < 0.05, Fig. 1A-B), including Glutathione S-transferase Pi (GSTP1), PILRA isoform FDF03-deltaTM; PILRA isoform FDF03-M14; GRN; α2-Antiplasmin (SERPINF2); MYZAP; BIN1; Siglec-3.