To examine whether CCR8 blockade suppresses liver cancer growth, we generated a monoclonal CCR8 antibody (Fig. S2-3, Table S1-3) named IPG0521, which bound CCR8 originated from human, monkey, dog, rat, and mouse with high affinity, and potently inhibited CCR8-mediated chemotaxis (Fig. 2A-C) and intracellular signaling (Fig. S3G-H). The gene discussed is CCR8; the disease is liver cancer.