Although we found its metabolic roles in decreased mitochondrial function, lower ATP, and increased intracellular ROS the most compelling, its protein has been associated with cancer phenotype as a factor promoting cell motility and invasion in pancreatic development [107], and it is upregulated by MAPK and PI3K/AKT, and Wnt/β-catenin signaling to initiate tumor development [108–109]. This evidence concerns the gene AKT1 and cancer.