Interestingly, among the 27 DEMRGs13, some genes including TP53, KEAP1, RAB34 and WNT3A were expressed more in the TCGA cancer groups with TM4SF5 overexpression (of LIHC, KIRC, COAD or STAD) than in TCGA cancer groups without TM4SF5 overexpression (of BRCA, SKCM, ACC or UCEC), whereas SNX1, GAB1 and GSK3B were expressed in the opposite pattern (Fig. 2f). Here, KEAP1 is linked to cancer.