As macropinocytosis involves the reuse of extracellular proteins or necrotic cell debris, it can be induced by PTEN deficiency and AMPK activation involving PIP3 accumulation and following energy stress, respectively; thus inhibition of macropinocytosis could be an effective strategy to target metabolism in late-stage prostate cancer, a tumor class known for its enigmatic nutrient dependency15. Here, PTEN is linked to neoplasm.