Considering the high expression of CD47, which is widespread in almost all immune cells and thus it is regarded as a new immune checkpoint molecule and a novel target in cancer immunotherapy studies (Li, 2019; Logtenberg et al, 2020; Takimoto et al, 2019; Veillette and Tang, 2019), we speculated that CD47 may play an important role in adaptive immunosuppression in sepsis. Here, CD47 is linked to cancer.