Degradation of the E3 ubiquitin ligase Tripartite Motif Containing 37 (TRIM37) protects TNF Receptor-Associated Factor 6 (TRAF6) from proteasomal degradation in the lung epithelium, which in turn promotes the production of NFκB-dependent chemokines to recruit neutrophils, creating the conditions for the formation of a pre-metastatic microenvironment for lung cancer [87]. Here, TRIM37 is linked to lung cancer.