Regarding the potential mechanism in pancreatic cancer, increases in the genera Acinetobacter, Pseudomonas, and Sphingopyxis, were positively correlated with DNA replication and oncogenic factors including K-ras signaling, EMT, and MAPK signaling, while being negatively correlated with bile acid metabolism, pancreatic beta cells, and pancreatic secretion [202]. This evidence concerns the gene KRAS and familial pancreatic carcinoma.