Single-cell RNA-sequencing of 34 samples from 20 recurrent HCC patients showed that the TME of truly recurrent HCC had more KLRB1 (Killer Cell Lectin Like Receptor B1, namely CD161)+CD8+ T cells with memory phenotype and low cytotoxicity, while the TME of de novo recurrent HCC had more cytotoxic and exhausted CD8+ T cells [112]. The gene discussed is CD8A; the disease is hepatocellular carcinoma.