F8 and Venous thrombosis: High levels of VWF and FVIII have been associated with an increased risk of thrombosis.34, 35At the same time, the release of VWF from Weibel Palade bodies can be triggered by cellular injury.36Thus, increased levels might be a sign of endothelial cell dysfunction, damage, or activation, presumably caused by VTE or at least more pronounced in patients with persisting functional limitations.37, 38We observed a comparable association of VWF and FVIII with functional limitations.