NOS2 and Alzheimer disease: Pharmacological intervention studies in mouse models of AD using selective inhibitors of NOS isozymes [122] that inhibit protein nitration [123]), as well as NADPH oxidase-2 inhibitors [[124], [125], [126]] and MPO inhibitors [127], may aid in defining the extent to which hemoglobin nitration plays a role in the pathogenesis of AD - or whether nitrated hemoglobin is a consequence of the disease process.