Apart from inhibiting the proliferation, migration, and invasion of CRC cells, and causing cell cycle arrest in the S phase, ICA also could effectively inhibit the expression of HSP90, and interfere the interaction with its potential client protein TXNDC9 possibly through direct binding, modulating programmed cell death (PCD), mainly apoptosis and autophage, in CRC cells. The gene discussed is HSP90AA1; the disease is colorectal carcinoma.