CASP8 and colorectal carcinoma: Finally, this cascade results in the induction of apoptosis.[26] As shown in Figure 3d, the protein levels of Caspase 3, Caspase 8, and Caspase 9 decreased with increasing concentrations of ICA, whereas the proteins levels of activated Cleaved‐caspase 3, Cleaved‐caspase 8, and Cleaved‐caspase 9 increased in both CRC cell lines.