In CRC, research has revealed that ICA could mediate the opening of mitochondrial permeability transition pores in CRC cells and induce cell death by activating the c‐Jun N‐terminal kinase (JNK) pathway.[15] Furthermore, ICA can induce p53 activation, leading to the suppression of AKT/mTOR signaling pathways, thereby inhibiting the proliferation of colon cancer cells.[16] However, the detailed mechanism is complicated and not clear yet. The gene discussed is TP53; the disease is colorectal carcinoma.