To further explore the biological functions of IRF8 in the inflammatory microenvironment of AAA tissue, we isolated primary bone marrow cells from the tibias and femurs of 8‐week‐old male mice and cultured them in RPMI 1640 medium supplemented with GM‐CSF and Flt3L to generate CD103+ dendritic cells (Figure6A).[20] Bone marrow‐derived dendritic cells (BMDCs) from Irf8‐OE mice exhibited a more mature phenotype, characterized by extensive protrusions and larger cell size (Figure S6A, Supporting Information). This evidence concerns the gene ITGAE and triple-A syndrome.