Fc gamma receptors are expressed in conventional dendritic cells and play a critical role in enhancing antigen uptake and presentation.[30] In our in vitro studies, we demonstrated that IRF8 promotes the expression of FcγRI (CD64) in cDC1s, a receptor known to facilitate cross‐presentation to CD8+ T cells, particularly during the early stages of immune responses.[23] By elucidating the IRF8‐cDC1‐CD8+ T cell axis and highlighting CLEC9A as a potential therapeutic target, we provide novel insights into the immunological mechanisms underlying AAA pathogenesis. Here, MPPE1 is linked to triple-A syndrome.