FGF21 and heart failure: For example, Fgf23‐knockout mice exhibit an accelerated senescence‐like phenotype[41] and FGF ligands and receptors are downregulated in aging tissues such as brain, bone, and skin.[42] In addition, studies revealed that FGF21 improves inflammatory response, indirectly delays cellular senescence, and directly plays an anti‐aging role by activating autophagy genes[43] Initially, we were interested in exploring the potential roles of lesser‐studied FGF family members, beyond the well‐known FGF21 and FGF23, in cardiac aging and heart failure.