We plotted the redox ratios of the NAD-related energy carrying molecules in neurons and astrocytes, in their respective cytoplasmic and mitochondrial compartments, and in both normal and GLUT1-DS conditions, including cytosolic NAD+/NADH (Fig 3a, top row), mitochondrial NAD+/NADH (Fig 3a, middle row), NADP+/NADPH in cytoplasm (Fig 3a, bottom row). The gene discussed is SLC2A1; the disease is Dravet syndrome.