We here found that overexpression of CREB in A375 BRAF-mutant melanoma cells resulted in upregulation of genes involved in glucose metabolism including Glycogen synthase kinase 3 beta (GSK3β), suggesting a novel role for CREB-activated pathways in metabolic rewiring, which may be required for the development of MAPKi resistance in melanoma (Supplementary Figure 1). The gene discussed is CREB1; the disease is melanoma.