STAT3 inhibition can effectively reduce the infiltration of inflammatory cells and alleviate renal inflammation.[40, 41] Albuminuria occurs in the early stages of diabetic nephropathy, persists over a considerable period of the disease process, and contributes to its progression.[42] However, reduced STAT3 activity through gene editing attenuates albuminuria, renal macrophage infiltration, and aberrant ECM accumulation in mice with STZ‐induced diabetic nephropathy. Here, STAT3 is linked to diabetic kidney disease.