IL1B and type 2 diabetes nephropathy: IL‐6 and IL‐1β mediate inflammatory damage in the kidney.[21, 22] IL‐6 is a primary cytokine that activates STAT3,[6] and serum IL‐6 levels of patients with type 2 diabetic nephropathy are significantly elevated, contributing to disease progression.[23, 24, 25] Notably, IL‐6 can further promote its expression through a positive feedback loop by activating STAT3, thereby enhancing and sustaining renal inflammation.[39, 43] This study revealed significantly elevated IL‐6 levels in the kidneys of db/db mice.