Self-assembling smart NPs were developed using amphiphiliccopolymer polyethylenimine-block-polylactic acid (PEI-PLA)/polyethyleneglycol-block-poly(l-aspartic acid sodium salt) (PEG-PASp)to load and deliver PTX and VEGF-siRNA and analyze its potential applicationin breast cancer treatment. The gene discussed is VEGFA; the disease is breast cancer.