VEGF secretion stimulates nearby endothelial cells(ECs), leadingthem to proliferate, migrate, and create new, albeit often abnormal,blood vessels due to the uncoordinated nature of angiogenesis in tumors.These vessels are frequently disorganized, highly permeable, and lackstructural support, resulting in a hypoxic and acidic tumor microenvironment(TME) that hinders immune cell infiltration, reduces radiotherapyefficacy, and limits drug delivery, ultimately favoring more aggressivecancer phenotypes.7,8. This evidence concerns the gene VEGFA and neoplasm.