VEGFA and breast carcinoma: In a study by Ultav et al., silica biocompatible NPs (SNPs) ofaround 30 nm in diameter were developed with a surface modificationby amination to achieve a positive charge, PEGylation conjugatingto prevent opsonization, with folic acid (SNP-FA) for active targeting,further complexed with VEGF-siRNA as a gene delivery system to exploitthe high amount of folate receptors on breast cancer cells.