Mesenchymal stem cells wereused as nanocarriers for the sFlt-1 gene, targeting vascular endothelialgrowth factor (VEGF)-driven angiogenesis in hepatocellular carcinoma.The study revealed that delivery of sFlt-1-secreting MSCs significantlyinhibited tumor growth and angiogenesis while preserving normal vascularfunctions in nontumoral tissues. The gene discussed is VEGFA; the disease is neoplasm.