The above formulation was effectivein inhibiting VEGFR2 and NRP-1, significantly suppressing the tubeformation and migration of ECs, inhibited glioma growth, and reducedthe microvasculature in orthotopic U87 glioma-bearing nude mice.65 Similarly, another study by Adeyemi et al. useda LyP-1 homing peptide as a targeting agent for the p32 receptor onthe outer layer of a polymeric PEI-PEG-chitosan-grafted nanosystemcontaining endostatin. This evidence concerns the gene PTPN22 and glioma.