SFN, an electrophilic compound enriched in cruciferous vegetables such as broccoli, is a known potent inducer of NFE2L2/NRF2 in various cell types including NPC cells (Figure 1—figure supplement 6), a transcriptional factor that controls the expression of multiple detoxifying enzymes through antioxidant response elements (AREs) (Yamamoto et al., 2018). This evidence concerns the gene NFE2L2 and nasopharyngeal carcinoma.