Recent efforts have focused on using Ad5-hAPN-transduced or hAPN transgenic mice, although these models require immunocompromised backgrounds, such as interferon alpha/beta receptor (IFNAR) or signal transducer and activator of transcription (STAT)-deficient mice [46, 47], and so may not accurately recapitulate the course of infection and host response. The gene discussed is SOAT1; the disease is infection.