The purple nodes represent IGFG, the blue nodules represent HE, and the pink nodes represent 12 common targets between IGFG and HE In the network, which are AKT1, BCL2, ESR1, F2, GPT, HIF1A, IL10, IL1B, OPRM1, TGFB1, Tumor necrosis factor (TNF), and HMOX1. This evidence concerns the gene ESR1 and hereditary elliptocytosis.