By conducting topological analysis on the PPI network, AKT1, TNF, MTOR, CHUK, PPP2CA, IKBKB, AKT2, IKBKG, IL1B, NFKBIA, and CASP8 are predicted to be the core targets of IGFG in treating HE (degree > 20). The gene discussed is CASP8; the disease is hereditary elliptocytosis.