In the context of HIV infection, cytokines play a pivotal role in orchestrating and regulating the immune response.[12] The immune system’s complex network of cytokines – small signaling proteins produced by various cells – serves as a fundamental component in the body’s defense against pathogens, including HIV.[13] When HIV infects a host, it primarily targets CD4+ T cells, which are central to coordinating immune responses.[14] The virus uses these cells as a replication site, ultimately leading to their destruction. This evidence concerns the gene CD4 and HIV infectious disease.