By targeting viral enzymes crucial for replication, such as reverse transcriptase, protease, and integrase, ART effectively reduces the viral load in the bloodstream.[25] Lowering viral replication rates helps control HIV infection and prevents the progression to acquired immunodeficiency syndrome (AIDS).[26] By suppressing viral replication, ART allows the immune system to recover.[27] It helps in restoring CD4+ T cell counts, which are vital for orchestrating immune responses. The gene discussed is CD4; the disease is HIV infectious disease.