IRF2BPL and epilepsy: Some studies have shown that IRF2BPL contains 2 highly conserved domains, the N-terminal and C-terminal zinc finger DNA binding domain and C3HC4 RING finger domain of IRF2BP, both of which are involved in transcriptional regulation.[22,23] Studies have shown that patients with pathogenic mutations in the poly Q domain have a higher incidence of epilepsy than patients with mutations in other fields.