It frequently involves the skin, kidneys, joints and gastrointestinal tract.[1] The etiology and pathogenesis of HSP are still unknown, and current studies prefer that HSP is an immune-responsive disease involving multiple inflammatory cells, cytokines, adhesion molecules, and oxidative stress mediated by IgA.[4] The disease is common in children but extremely rare in adults, with an incidence of only 1.3 per 100,000. The gene discussed is CD79A; the disease is hereditary spastic paraplegia.