VEGFA and neoplasm: As VEGF is secreted, the tumor becomes neovascularized without the BBB, and the tumor itself secretes cytokines or proteins to damage the tight junction or basement membrane, ultimately leading to BBB breakdown.[3,5–8] Therefore, when contrast-enhanced MRI is performed, the tumor is enhanced as the contrast media penetrates through the capillaries where the BBB is disrupted.[3] In addition, when permeability increases due to BBB breakdown, serum proteins such as albumin and immunoglobulin G also extravasate into the interstitium.