From the comparison of the NMR profiles, we observed that HCC patients have significantly higher levels of cholesterol, some LDL subclasses, some HDL subclasses, Isoleucine, Valine, Triglycerides, Lactate, Alanine, Albumin and AFP, and significant lower levels of HDL_s, Dimethylamine, Glycerol and total Bilirubin. This evidence concerns the gene ALB and hepatocellular carcinoma.