The pooled estimate showed no significant difference in the incidence of all-cause dementia between users of mixed AHMs and Ang-II inhibiting AHMs (HR = 0.98, 95% CI = 0.77–1.24, p = 0.85), with significant heterogeneity (chi2 = 45.25, p < 0.01, I2 = 95.3%) (Fig. S8). This evidence concerns the gene AGT and dementia.