AGT and dementia: Subgroup analyses showed that Ang-II stimulating AHMs were associated with a significantly reduced risk of all-cause dementia compared with Ang-II inhibiting AHMs in studies that adjusted for confounders (HR = 0.85, 95% CI = 0.81–0.89, p < 0.001, n = 6) [18, 24–26, 52, 54], but not in those studies that did not adjusted for confounders (HR = 1.01, 95% CI = 0.91–1.13, p = 0.83, n = 2) [51, 53] (Fig. S2).