The 55 genes listed in the Guidelines for the Communication Process in Genomic Medicine [15, 16] were selected for the Fact Sheet (Table 1), all of which were cancer predisposition genes except for four genes: HNF1A, SMAD3, TGFBR1, and TGFBR2. All members of the Genetic Specialist Committee agreed on the selected genes. This evidence concerns the gene SMAD3 and cancer.