In (Marquez et al. 2014), the radioconjugate 89Zr-DOTA-pertuzumab tested on BT-474 (HER2 +) and MDA-MB-231 (HER2-) tumour-xenografted NOG mice showed the uptake in spleen over 100% ID/g, even though the uptake in Nu/Nu strain was under 3% ID/g. The gene discussed is ERBB2; the disease is neoplasm.