ERBB2 and neoplasm: In work of (Borchardt et al. 2003) the uptake of 111In-DOTA-trastuzumab in spleen of tumour-xenografted athymic nude mice was around 15% at 24 h p.i. On the other hand, the same conjugate showed uptake of almost 40% ID/g in spleen when tested in HER2 + tumour-xenografted NRG mice.