TNFSF11 and osteoporosis: On the other hand, in the osteoporosis model adopted in the present study, the bone process of reabsorption/neoformation is significantly altered and harmed, since there's an imbalance in the RANK/RANKL/OPG system that increases the proliferation of osteoclasts and, consequently, stimulates bone resorption (Khosla & Riggs, 2005).